NYU Langone Insights on Psychiatry
Conversations about complex psychiatric cases and evolving treatments. Host Charles Marmar, MD, Chair of Psychiatry at NYU Grossman School of Medicine, speaks with NYU Langone faculty about diagnostic reasoning, treatment decisions, and the ethical questions that arise in clinical practice.
Episodes
Closing the Revolving Door of Severe Mental Illness
Bipin Subedi, MD, explores how health systems can better care for patients with severe mental illness who cycle between hospitals, homelessness, addiction, and the justice system. He argues that acute inpatient treatment, while essential, is rarely sufficient on its own. Preventing the revolving door of repeated hospitalizations requires psychiatry to extend beyond hospital walls and build integra
Diagnosing Autoimmune Psychosis
Katlyn Nemani, MD, explores how autoimmune and inflammatory brain disorders can present as first-episode psychosis—and why some patients diagnosed with schizophrenia may actually have a treatable immune-mediated illness. She explains the clinical features that should prompt suspicion for autoimmune psychosis, including subacute onset, subtle neurologic signs, and poor response to antipsychotics, e
The Neuropsychiatry of Complex Brain Injury Care
Lindsey Gurin, MD, discusses how clinicians can approach patients whose symptoms fall at the intersection of psychiatry and neurology. Drawing on her work with traumatic brain injury, PTSD, and persistent post-concussive symptoms, she explains why attempts to separate psychological trauma from neurological injury often obscure what patients actually need.The conversation explores identity disrupti
Psychedelics for Treatment-Resistant Disorders
Michael Bogenschutz, MD, explains how psychedelic-assisted treatments may offer new options for patients with severe, treatment-refractory psychiatric conditions. He discusses why standard approaches often fall short for complex cases, how psychedelics like psilocybin and MDMA differ from conventional medications, and what careful screening and clinical structure make these treatments safe and eff
Treating ADHD in Patients With Bipolar Disorder and Substance Use
Lenard Adler, MD, explains how clinicians can safely and effectively treat ADHD when bipolar disorder and addiction are also in the picture. He addresses how to distinguish chronic ADHD symptoms from episodic mood disorders, why bipolar disorder is often missed in adults referred for depression or attention problems, and how substance use complicates both diagnosis and medication selection.Dr. Adl
Delivering Addiction Care Outside Traditional Settings
Ayana Jordan, MD, PhD, discusses how precision psychiatry must expand beyond biology to address the social, cultural, and structural realities shaping addiction and mental health care for historically underrepresented patients. The conversation explores how trauma, poverty, housing instability, health literacy, and stigma interact with substance use and serious mental illness—and why traditional c
Bipolar Depression and Mixed Episodes: Rethinking Treatment Goals
Dan Iosifescu, MD, discusses why bipolar depression and mixed episodes remain among the most difficult—and highest-risk—conditions in psychiatry. Even when mood symptoms improve, many patients continue to experience significant cognitive and functional impairment. Dr. Iosifescu argues that standard approaches often fall short because symptom suppression is mistaken for recovery, short-term improve
Interventional Approaches to Treatment-Resistant Mood Disorders
Joshua Berman, MD, PhD, discusses how careful evaluation, patient priorities, and risk-benefit tradeoffs guide the use of interventional treatments when conventional approaches fall short. Dr. Berman also explains how tools such as ketamine, TMS, ECT, and neurofeedback can be used strategically—sometimes in sequence or combination—to address different vulnerabilities within mood-related brain circ
The State of Precision Psychiatry
To kick off Season 4, Charles Marmar, MD, explains how precision psychiatry is reshaping the way clinicians and researchers think about diagnosis, treatment selection, and the underlying biology of psychiatric disorders. This conversation is a overview of where the field stands today—including emerging molecular markers, biologically informed subtypes, and new translational approaches inspired by
The Next Big Breakthrough
What if mental health care worked more like cancer treatment—tailored to the individual, informed by biology, and driven by data? Charles Marmar, MD, Chair of Psychiatry at NYU Grossman School of Medicine, takes us through the latest advances in precision psychiatry. From brain imaging to digital phenotyping, Dr. Marmar outlines the tools shaping a future where treatment is fully customized. He al
The Schizophrenia Puzzle is Solvable
There’s a care model for schizophrenia that actually works—why isn’t it everywhere? On this episode, W. Gordon Frankle, MD, MBA, Vice Chair of Psychiatry at NYU Langone Health, shares how his team in Brooklyn is building a new model for treating serious mental illness—one rooted in long-term, relationship-driven, team-based care. From wraparound services to precision psychiatry, this conversation
How Psychedelics Rewire the Brain
How could a single psychedelic treatment cause lasting change? Joshua Siegel, MD, PhD, is on a mission to find out. A leading expert on neuroimaging and neuropsychopharmacology at NYU Langone’s Center for Psychedelic Medicine, Dr. Siegel unpacks how psilocybin may spark neuroplasticity and reshape the depressed brain. He also gives us an inside look at the race to develop non-hallucinogenic psyche
Can AI Help Prevent PTSD?
What if a simple conversation in the emergency room could reveal who’s most at risk for PTSD before symptoms even begin? Katharina Schultebraucks, PhD, shares her innovative work on using machine learning to forecast mental health outcomes and explains how AI could revolutionize how we detect, prevent, and treat psychiatric disorders. Dr. Schultebraucks is Co-Director of the Computational Psychiat
ADHD at School: What Actually Helps
How do you help a child with ADHD stay organized, on task, and confident in school? Richard Gallagher, PhD, a child and adolescent psychologist at NYU Langone Health, shares groundbreaking research on organizational skills training for children with ADHD—a behavioral treatment that’s changing lives and improving classroom performance. This episode dives into how executive functioning challenges ma
The Hidden Adult ADHD Crisis
ADHD isn’t just a childhood condition—many adults go undiagnosed for years. Lenard Adler, MD, Director of the Adult ADHD Program at NYU Langone Health, breaks down the nuances of ADHD in adults, the challenges of proper diagnosis, and the latest treatments available. Learn about his research, the screening tools his team has developed, and what’s on the horizon for adult ADHD care.🔍 Topics Covered
How to Make Addiction Care Routine
Despite affecting more Americans than diabetes, substance use is often left out of routine medical care. In this episode, NYU Langone Health’s Jennifer McNeely, MD—a clinician investigator, primary care and addiction medicine physician—explains why that must change. From the surprising history behind addiction’s exclusion from mainstream medicine to the innovative screening tools shaping the futur
The Key to Effective Addiction Care
What makes addiction treatment truly effective? Behavioral scientist Charles Neighbors, MBA, PhD, shares groundbreaking research on the importance of therapeutic relationships, harm reduction, and human connection—love!—in treating substance use disorders. Dr. Neighbors is an Associate Professor in the Departments of Population Health, and Psychiatry at NYU Grossman School of Medicine.💡 Topics Cov
Pediatric ADHD: Precision Strategies (with Samuele Cortese, MD, PhD)
For the final episode of Season 2, we're joined by Dr. Samuele Cortese, Professor of Child and Adolescent Psychiatry at the University of Southampton (UK) and Adjunct Full Professor at NYU Langone. Together we explore the intersection of pediatric ADHD and precision psychiatry, including the disorder’s genetic underpinnings and evolving treatment options.00:00 Introduction00:54 Dr. Cortese&ap
Pediatric ADHD: A Lifespan Approach (with Timothy Wilens, MD)
Dr. Timothy Wilens is a Professor of Psychiatry at Harvard Medical School and Chief of the Division of Child and Adolescent Psychiatry at Massachusetts General Hospital. His research interest include the relationship between ADHD, bipolar disorder, and substance use disorders; ADHD pharmacotherapy; and stimulant medication misuse.On this episode, Dr. Wilens discusses the importance of early diagno
Schizophrenia (with Ira Glick, MD)
Dr. Ira Glick is Professor Emeritus of Psychiatry and Behavioral Sciences at Stanford University Medical Center, where he has served as director of the Schizophrenia Research Clinic. On this episode, he discusses his research journey, which began in the 1960s and followed a shift from psychoanalysis to biological psychiatry. He addresses the broken social safety net for schizophrenia patients, inc
Mental Health Equity (with Christin Drake, MD)
Dr. Christin Drake is Clinical Associate Professor and Vice Chair of Diversity and Equity in the Department of Psychiatry at NYU Grossman School of Medicine. On this episode, Dr. Drake discusses ongoing efforts to improve mental health equity, including by improving psychiatric services for underserved groups, gathering better data, and boosting diversity among health care providers. She also disc
Ketamine (with John Krystal, MD)
Dr. John Krystal is Chair of Psychiatry at the Yale School of Medicine. He is best known for leading the discovery of the rapid antidepressant effects of ketamine, which paved the way for the first major new antidepressant drug in decades. Here, Dr. Krystal talks about what we’ve learned in the five years since esketamine nasal spray was approved by the FDA, including efforts to predict treatment
Struggling Kids & Teens (with Robert Findling, MD)
Dr. Robert Findling is Chair of the Department of Psychiatry at the Virginia Commonwealth University School of Medicine. Here he discusses recent advances in pediatric mental health, including his own research on aggression and schizophrenia in young people. Dr. Findling also shares his thoughts on the crisis of teen suicide, the lingering impact of COVID-19 on children’s mental health, and the ne
Frontiers of Psychopharmacology (with Charles Nemeroff, MD, PhD)
Dr. Charles Nemeroff is Chair of the Department of Psychiatry and Behavioral Sciences at the University of Texas-Austin's Dell Medical School. He is also co-director of the Center for Psychedelic Research and Therapy, and director of the Institute for Early Life Adversity Research. His research is focused on the pathophysiology of mood and anxiety disorders with a focus on the role of child a
Empathy Training (with Helen Riess, MD)
Dr. Helen Riess is Associate Clinical Professor of Psychiatry at Harvard Medical School and Director of Empathy Research and Training in the Psychotherapy Research Group at Massachusetts General Hospital. She is also Founder and Chief Executive Officer at Empathetics, a company that provides science-based empathy and interpersonal skills training for healthcare professionals. Her research focuses
Obsessive-Compulsive Disorder (with Christopher Pittenger, MD, PhD)
Dr. Christopher Pittenger is a Professor of Psychiatry at the Yale School of Medicine and Director of the Yale OCD Research Clinic. In this episode, he discusses the neurobiology, symptomology, and treatment of Obsessive-Compulsive Disorder (OCD), including potential new treatments such as psychedelics, neurofeedback, glutamate modulators, and transcranial magnetic stimulation (TMS). 00:00 Introdu
Meditation (with Richard Davidson, PhD)
Dr. Richard Davidson is the William James and Vilas Professor of Psychology and Psychiatry at the University of Wisconsin–Madison and Founder & Director of the Center for Healthy Minds. In this episode, he discusses the current state of research on mindfulness and meditation as mental health interventions.00:00 Introduction02:15 Focus areas in current research04:37 Well-being as a universal i
Precision Psychiatry (with Ronald Kessler, PhD)
Dr. Ronald Kessler is the McNeil Family Professor of Health Care Policy at Harvard Medical School. His groundbreaking work on the social determinants of mental health, studied from an epidemiological perspective, has made him the most widely cited psychiatric researcher in the world. In this wide-ranging conversation, he talks about precision psychiatry's enormous potential and incremental d
Addiction (with Petros Levounis, MD, MA)
Dr. Petros Levounis is President of the American Psychiatric Association and a leader in addiction research. He joins host Thea Gallagher, PsyD, to talk about the latest in addiction medicine, the state of the opioid crisis, the growing problem of technology addiction, and the promise and risks of psychedelic medicine. He also shares his hopes for the future of psychiatry, including better integra
Season 2 Announcement
Starting this fall, we're releasing 12 more conversations with the best minds in psychiatry. Subscribe wherever you're listening, so you won't miss an episode.This discussion is for educational purposes and does not substitute for individual clinical judgment or patient care.Senior Producer: Jon Earle
Biomarkers for Depression (with Carla Nasca, PhD)
Dr. Carla Nasca is an Assistant Professor in the Department of Psychiatry and the Department of Neuroscience and Physiology at NYU Langone, where she studies epigenetic mechanisms of neuroplasticity to stress. Dr. Nasca's work led to the discovery of acetyl-L-carnitine (LAC), a metabolite found in the mitochondria, as a promising biological marker of depression.Topics:acetyl-L-carnitine (LAC)
Dopamine (with Tanya Sippy, MD, PhD)
Dr. Tanya Sippy is an Assistant Professor in the Department of Psychiatry and the Department of Neuroscience and Physiology at NYU Langone. She’s also Principal Investigator at the Sippy Lab and Associate Director of the Psychedelic Medicine Research Training Program. Her research explores the neural mechanisms that underlie how sensory stimuli become associated with goal-directed behavior. Topics
Bipolar Disorder (with Andrew Nierenberg, MD)
Dr. Andrew Nierenberg is a Professor of Psychiatry at Harvard Medical School and Director of the MGH Dauten Family Center for Bipolar Treatment Innovation. He completed his residency in psychiatry at New York University/Bellevue Hospital.Topics:Lithium vs antipsychoticsSMART BD (Sequential Multiple Assignment of Randomized Treatment)Bipolar Learning Health NetworkMedication concordanceMore informa
Depressive Disorders (with Alan Schatzberg, MD)
Dr. Alan Schatzberg is a Professor of Psychiatry and Behavioral Sciences at Stanford Medicine, and Director of the Stanford Mood Disorders Center. His research examines the biology and psychopharmacology of depressive disorders. An NYU School of Medicine alumnus, Dr. Schatzberg was President of the American Psychiatric Association from 2009-2010.Topics:Ketamine and Esketamine (incl. mechanisms of
Psychedelic Medicine (with Michael Bogenschutz, MD)
Dr. Michael Bogenschutz is a Professor of Psychiatry at the NYU Grossman School of Medicine, and Director of the NYU Langone Center for Psychedelic Medicine.Topics:Psilocybin-assisted psychotherapy for alcohol use disorderMDMA-assisted psychotherapy for PTSDPsychedelic medicine for the "worried well"The role of the mystical experienceComparing different psychedelic medicinesMechanisms of
Sleep and Alzheimer's Disease (with Omonigho M. Bubu, MD, MPH, PhD)
Dr. Omonigho M. Bubu is an Assistant Professor of Psychiatry and Population Health at the NYU Grossman School of Medicine, where he studies the connection between sleep and neurodegenerative diseases, as well as social determinants of health as they relate to cognitive health. In this interview, he discusses the importance of sleep, especially for people at higher risk of developing Alzheimer’s di
Mindfulness-Based Stress Reduction (with Naomi Simon, MD)
Naomi Simon, MD, talks about her research into mindfulness-based stress reduction (MBSR) and yoga as treatments for anxiety disorders. Dr. Simon is a Professor in the Department of Psychiatry at the NYU Grossman School of Medicine, and Director of the Anxiety, Stress, and Prolonged Grief Program.Topics:Generalized Anxiety Disorder (GAD)Mindfulness-Based Stress Reduction (MBSR)Kundalini yogaSelecti
Fear Conditioning (with Mohammed Milad, PhD)
Mohammed Milad, PhD, discusses recent research into fear conditioning, regulation, and extinction. Dr. Milad is a Professor in the Department of Psychiatry at the NYU Grossman School of Medicine and Director of the Behavioral Neuroscience Program.Topics covered:Transcranial magnetic stimulation (TMS)Estrogen and PTSDPost-traumatic stress disorder (PTSD)MeditationDeep brain stimulationThis discussi
Health Equity (with Ayana Jordan, MD, PhD)
Ayana Jordan, MD, PhD, is the Barbara Wilson Associate Professor of Psychiatry at the NYU Grossman School of Medicine, an Associate Professor in the Department of Population Health, and the Pillar Lead for the Institute for Excellence in Health Equity.Topics covered:Lack of improvement in health equity nationwideAdvice for clinicians on providing equitable careStructural competence vs. cultural co
Adult ADHD (with Lenard Adler, MD)
Lenard A. Adler, MD, is a Professor of Psychiatry and Child and Adolescent Psychiatry at the NYU Grossman School of Medicine and Director of the Adult ADHD Program at NYU Langone Health. Topics covered:Symptomology (incl. sluggish cognitive tempo)Screening and diagnostic toolsPharmacological treatments (and recent developments)Cognitive behavioral therapy (CBT)Medication shortageApproaches to trea
Treatment-Resistant Depression (with Dan Iosifescu, MD)
Dan Iosifescu, MD, is an Associate Professor of Psychiatry at the NYU Grossman School of Medicine and director of clinical research at the Nathan Kline Institute for Psychiatric Research. His research has led to the validation of novel treatments for patients with severe mood and anxiety disorders, including pharmacological treatments such as ketamine and other glutamatergic drugs, and devices suc
PTSD & Precision Medicine (with Charles Marmar, MD)
Charles R. Marmar, MD, is the Peter H. Schub Professor of Psychiatry and Chair of the Department of Psychiatry at NYU Langone Health. He also serves as Director of the Center for Precision Medicine in Alcohol Use Disorders and Post-Traumatic Stress Disorder (PTSD) and as Executive Director of the Steven A. Cohen Military Family Center.Topics covered:The shortcomings of existing "gold-standard
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