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Hart2Heart with Dr. Mike Hart

Hart2Heart with Dr. Mike Hart

Dr. Mike Hart 228 Episodes Aug 20, 2026

Hart2Heart is a health and wellness podcast hosted by Dr. Mike Hart, focusing on evidence-based strategies for longevity, performance, and modern medicine. Episodes cover topics like hormone health, peptides, sleep, nutrition, supplements, exercise, sunlight, psychedelics, and smarter medication use. The show also examines how public health policy and politics affect personal well-being and aims to help listeners take control of their health. It offers clear, actionable, no-nonsense conversations about living healthier and thinking independently.

Episodes

#234 Navigating Weight Loss: Breaking Down Barriers with Dan Go
#234 Navigating Weight Loss: Breaking Down Barriers with Dan Go Aug 20, 2026 01:01:13 After a five-year hiatus, Dan Go returns to break down a sustainable approach to fat loss for busy people who do not have hours to spend in the gym. He explains why identifying the main physiological or psychological bottleneck—such as late-night eating, stress, grazing, or weekend overeating—can matter more than simply handing someone a meal plan. The conversation covers calorie tracking for awar
#233 Understanding NAD+: Insights with Dr. Charles Brenner
#233 Understanding NAD+: Insights with Dr. Charles Brenner Aug 13, 2026 01:01:20 Charles Brenner breaks down what the science actually says about NAD+, separating established findings from the claims commonly made in the longevity space. He explains why NAD levels in tissues may matter more than blood measurements, how metabolic stress, alcohol, inflammation, and other conditions can disrupt the NAD system, and how nicotinamide riboside (NR) compares with niacin, nicotinamide,
#233 Understanding NAD+: Insights with Dr. Charles Brenner
#233 Understanding NAD+: Insights with Dr. Charles Brenner Aug 13, 2026 01:01:20 Charles Brenner breaks down what the science actually says about NAD+, separating established findings from the claims commonly made in the longevity space. He explains why NAD levels in tissues may matter more than blood measurements, how metabolic stress, alcohol, inflammation, and other conditions can disrupt the NAD system, and how nicotinamide riboside (NR) compares with niacin, nicotinamide,
#232 Testosterone Screening, Metabolic Health, and Hormone Optimization: Free T, SHBG, hCG, and Body Composition
#232 Testosterone Screening, Metabolic Health, and Hormone Optimization: Free T, SHBG, hCG, and Body Composition Aug 6, 2026 55:48 This episode explores the opportunities and risks of testosterone optimization, beginning with the US military's decision to screen men over 30 for low testosterone. Dr. Mike Hart and Dr. Jonathan Schoeff discuss why symptoms such as fatigue, low libido, and difficulty changing body composition cannot be interpreted from a single lab value. They examine the importance of free testosterone, SHBG, i
#231 Dr. Kyle Gillett on Nootropics, Peptides, GLP-1 Side Effects, Hair Loss, and Microplastics
#231 Dr. Kyle Gillett on Nootropics, Peptides, GLP-1 Side Effects, Hair Loss, and Microplastics Jul 30, 2026 01:11:54 Dr. Kyle Gillett joins Dr. Mike Hart to discuss safer, more practical approaches to biohacking, performance, and longevity. They cover indoor microplastic exposure, bromantane, low-dose nicotine, healing peptides, BPC-157 safety, tesamorelin, growth hormone, GLP-1 digestive side effects, NAD support, carnitine, hair loss, sleep medications, and longevity treatments. Dr. Gillett separates promising
#230 Progesterone for Sleep, GLP-1 Microdosing, and HRT/Peptide Insights with Dr. K
#230 Progesterone for Sleep, GLP-1 Microdosing, and HRT/Peptide Insights with Dr. K Jul 23, 2026 01:09:37 Dr. Mike Hart welcomes Ksenia Petrushkina back for a wide-ranging conversation about using hormones, GLP-1 medications, and peptides more thoughtfully. They explore why lower, individualized doses of tirzepatide may improve tolerability, which blood markers should be monitored during treatment, and how progesterone may support sleep through its effects on GABA. They also discuss women's hormone re
#229 Supplements, Methylation, and Genetics: Why "Healthy" Stacks Can Trigger Anxiety
#229 Supplements, Methylation, and Genetics: Why "Healthy" Stacks Can Trigger Anxiety Jul 16, 2026 01:22:28 Dr. Tyler Panzner joins Dr. Mike Hart to explain how genetics, supplement combinations, and individual brain chemistry can influence anxiety, irritability, brain fog, and the persistent "monkey on your back" feeling. They examine why the MTHFR gene is scientifically valid but often overmarketed, and why methylated B vitamins, SAMe, creatine, phosphatidylcholine, and other methylation-related suppl
#228 Minoxidil for Hair Loss: Topical vs Oral, Tretinoin, and Microneedling
#228 Minoxidil for Hair Loss: Topical vs Oral, Tretinoin, and Microneedling Jul 9, 2026 31:33 The episode explains how to use minoxidil for hair loss, emphasizing that it supports follicles and prolongs the anagen phase but does not block DHT (with topical dutasteride mentioned as a scalp-focused DHT option). It reviews evidence that 5% topical minoxidil is optimal (better than 2% and superior to 10%), works best on the crown/vertex, and should be applied to the scalp—not the hair—with exp
#227 Diet Update: High-Protein, High-Fiber Meal Plan Built for Training and Consistency
#227 Diet Update: High-Protein, High-Fiber Meal Plan Built for Training and Consistency Jul 2, 2026 29:03 The speaker shares a structured, consistent diet designed to support hard training (three strength sessions, Norwegian 4x4, Zone 2 cardio, and one MMA session weekly), reduce "food noise," and stay full with high protein and fiber. He explains cooling/freezing rice to increase resistant starch and lower glycemic impact, then details his daily routine: a morning shake with creatine, collagen peptid
#226 Viewpoint Diversity, Physician-Assisted Suicide, AI, and Human Dignity in Medicine
#226 Viewpoint Diversity, Physician-Assisted Suicide, AI, and Human Dignity in Medicine Jun 25, 2026 01:01:09 Dr. Kristin Collier joins Dr. Mike Hart to discuss the ethical, cultural, and technological forces reshaping modern medicine. Reflecting on the 2022 white coat speech walkout, she explores viewpoint diversity, self-censorship, moral courage, and the importance of cultivating wisdom alongside technical skill in medical education. The conversation also examines physician-assisted suicide, its relati
#225 GLP-1 Masterclass: Dosing, Optimal Use, Lifestyle Changes, and Benefits Beyond Weight Loss
#225 GLP-1 Masterclass: Dosing, Optimal Use, Lifestyle Changes, and Benefits Beyond Weight Loss Jun 18, 2026 59:17 This episode explores how to use GLP-1 medications like semaglutide/Ozempic and tirzepatide/Mounjaro safely and effectively. Dr. Mike Hart and Dr. Christle Guevarra Do discuss once-weekly dosing, individualized titration, optimal dose selection, food noise, appetite suppression, and the risks of dosing mistakes with vials or gray-market peptides. They also cover why resistance training, protein, f
#224 Dr. Alex Tatum on Peptides, FDA Crackdowns, TRT Nuance, and Safe Penis Enhancement
#224 Dr. Alex Tatum on Peptides, FDA Crackdowns, TRT Nuance, and Safe Penis Enhancement Jun 11, 2026 01:06:29 Dr. Mike Hart interviews board-certified urologist Dr. Alex Tatum about peptide access, compounding, and men's health. Tatum argues many peptides are naturally occurring and lacked FDA commercialization incentives, says the FDA's 2023 move banning 19 compounds from Category 1 was contested due to no produced adverse-safety evidence, and describes the patient impact and advocacy around a July PCAC

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