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Hart2Heart with Dr. Mike Hart

Hart2Heart with Dr. Mike Hart

Dr. Mike Hart 228 Episodes Oct 8, 2026

Hart2Heart is a health and wellness podcast hosted by Dr. Mike Hart, focusing on evidence-based strategies for longevity, performance, and modern medicine. Episodes cover topics like hormone health, peptides, sleep, nutrition, supplements, exercise, sunlight, psychedelics, and smarter medication use. The show also examines how public health policy and politics affect personal well-being and aims to help listeners take control of their health. It offers clear, actionable, no-nonsense conversations about living healthier and thinking independently.

Episodes

#241 Decriminalization, Healthcare, and the Future of Medicine with Dr. Ira Price
#241 Decriminalization, Healthcare, and the Future of Medicine with Dr. Ira Price Oct 8, 2026 01:25:18 Dr. Mike Hart and Dr. Ira Price explore how medicine is adapting as patients gain greater access to emerging treatments, health information, and tools once limited to physicians. They discuss unapproved peptides and GLP-1 drugs, the growing shift toward personalized and patient-centered care, and the challenges doctors face when evidence and regulation lag behind real-world use. The conversation e
#240 Dr. Spencer Nadolsky on Repatha, ApoB Targets, and What Actually Matters in Lipidology
#240 Dr. Spencer Nadolsky on Repatha, ApoB Targets, and What Actually Matters in Lipidology Oct 1, 2026 01:03:19 Dr. Mike Hart sits down with lipidologist Dr. Spencer Nadolsky for a practical discussion on cardiovascular prevention, cholesterol management, and metabolic health. They break down how to interpret ApoB, LDL, HDL, triglycerides, and Lp(a), when cholesterol-lowering medications may make sense, and why long-term exposure matters when thinking about heart disease risk. The conversation also explores
#239 Oral Peptides: How They Work Without Entering the Bloodstream
#239 Oral Peptides: How They Work Without Entering the Bloodstream Sep 24, 2026 20:28 Dr. Mike Hart discusses how oral peptides can still have biological effects despite limited or no systemic absorption, using examples including KPV, BPC-157, linaclotide (Constella), oral semaglutide, and cyclosporine. He explains protein digestion into dipeptides/tripeptides and the PEPT1 transporter that moves some small peptides into enterocytes for local cellular effects, noting that KPV can a
#238 The Science of Hormones: Birth Control, HRT, and Thyroid with Dr. Masghati
#238 The Science of Hormones: Birth Control, HRT, and Thyroid with Dr. Masghati Sep 17, 2026 01:09:46 In this episode, Dr. Mike Hart and OB-GYN Dr. Salome Masghati examine how common hormone interventions can affect women far beyond pregnancy prevention or symptom relief. They discuss the risks and tradeoffs of different birth control options, possible effects on mood, libido, testosterone, and attraction, and why individual responses can vary significantly. The conversation then explores when to
#237 Oral Health, Blood Pressure, and Better Hygiene: Dr. Eilon on Toothpaste, Mouthwash, and Whitening
#237 Oral Health, Blood Pressure, and Better Hygiene: Dr. Eilon on Toothpaste, Mouthwash, and Whitening Sep 10, 2026 01:25:22 Dr. Mike Hart sits down with Dr. Ilon Choai to unpack everyday dental habits and the connection between oral and overall health. They discuss choosing toothpaste, fluoride versus nano-hydroxyapatite, and how mouthwash may affect the oral microbiome. Dr. Choai shares his approach to brushing, flossing, tongue scraping, and managing dietary acid exposure, while explaining teeth-whitening options, ad
#236 The Cannabis Cure Controversy: Lee Whitley's Bold Claims
#236 The Cannabis Cure Controversy: Lee Whitley's Bold Claims Sep 3, 2026 01:24:55 In this episode, Dr. Mike Hart sits down with Lee Whitley and physician Dr. Ira Price for a wide-ranging discussion about Lee's proprietary cannabis formulation and the extraordinary cancer-treatment claims surrounding it. Lee shares his own experience with stage IV squamous cell throat cancer, patient case stories, oral and injectable applications, dosing, and alleged pharmaceutical acquisition o
#235 Dr. Leigh Erin Connealy on Preventing Cancer: Lifestyle, Toxins, Hormones, Fasting, and Screening Beyond Tumors
#235 Dr. Leigh Erin Connealy on Preventing Cancer: Lifestyle, Toxins, Hormones, Fasting, and Screening Beyond Tumors Aug 27, 2026 01:06:14 In this episode, Dr. Mike Hart sits down with Dr. Leigh Erin Connealy for a wide-ranging conversation on cancer prevention and the factors she believes influence long-term health. Dr. Connealy shares her perspective on why cancer should be approached as a whole-body problem, exploring the roles of nutrition, metabolic health, environmental toxins, sleep, stress, hormones, and mitochondrial functio
#234 Navigating Weight Loss: Breaking Down Barriers with Dan Go
#234 Navigating Weight Loss: Breaking Down Barriers with Dan Go Aug 20, 2026 01:01:13 After a five-year hiatus, Dan Go returns to break down a sustainable approach to fat loss for busy people who do not have hours to spend in the gym. He explains why identifying the main physiological or psychological bottleneck—such as late-night eating, stress, grazing, or weekend overeating—can matter more than simply handing someone a meal plan. The conversation covers calorie tracking for awar
#233 Understanding NAD+: Insights with Dr. Charles Brenner
#233 Understanding NAD+: Insights with Dr. Charles Brenner Aug 13, 2026 01:01:20 Charles Brenner breaks down what the science actually says about NAD+, separating established findings from the claims commonly made in the longevity space. He explains why NAD levels in tissues may matter more than blood measurements, how metabolic stress, alcohol, inflammation, and other conditions can disrupt the NAD system, and how nicotinamide riboside (NR) compares with niacin, nicotinamide,
#232 Testosterone Screening, Metabolic Health, and Hormone Optimization: Free T, SHBG, hCG, and Body Composition
#232 Testosterone Screening, Metabolic Health, and Hormone Optimization: Free T, SHBG, hCG, and Body Composition Aug 6, 2026 55:48 This episode explores the opportunities and risks of testosterone optimization, beginning with the US military's decision to screen men over 30 for low testosterone. Dr. Mike Hart and Dr. Jonathan Schoeff discuss why symptoms such as fatigue, low libido, and difficulty changing body composition cannot be interpreted from a single lab value. They examine the importance of free testosterone, SHBG, i
#231 Dr. Kyle Gillett on Nootropics, Peptides, GLP-1 Side Effects, Hair Loss, and Microplastics
#231 Dr. Kyle Gillett on Nootropics, Peptides, GLP-1 Side Effects, Hair Loss, and Microplastics Jul 30, 2026 01:11:54 Dr. Kyle Gillett joins Dr. Mike Hart to discuss safer, more practical approaches to biohacking, performance, and longevity. They cover indoor microplastic exposure, bromantane, low-dose nicotine, healing peptides, BPC-157 safety, tesamorelin, growth hormone, GLP-1 digestive side effects, NAD support, carnitine, hair loss, sleep medications, and longevity treatments. Dr. Gillett separates promising
#230 Progesterone for Sleep, GLP-1 Microdosing, and HRT/Peptide Insights with Dr. K
#230 Progesterone for Sleep, GLP-1 Microdosing, and HRT/Peptide Insights with Dr. K Jul 23, 2026 01:09:37 Dr. Mike Hart welcomes Ksenia Petrushkina back for a wide-ranging conversation about using hormones, GLP-1 medications, and peptides more thoughtfully. They explore why lower, individualized doses of tirzepatide may improve tolerability, which blood markers should be monitored during treatment, and how progesterone may support sleep through its effects on GABA. They also discuss women's hormone re

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